Sniffing Out Biomarkers Using Chromatography: HS-GC-MS in Medical Device Development

Sniffing Out Biomarkers Using Chromatography: HS-GC-MS in Medical Device Development

CPG used headspace solid-phase microextraction gas chromatography-mass spectrometry to generate unique, chromatographic fingerprints from the urine of cancer patients relative to biopsy-negative controls. Researchers from MIT and John Hopkins then used the HS SPME GC-MS information in combination with data from trained cancer detection dogs to train an artificial neural network (ANN) to emulate canine […]

UHMWPE Testing for Medical Device Development

UHMWPE Testing for Medical Device Development

Highly Crosslinked UHMWPE for Hip & Knee Arthoplasties A discovery by researchers at CPG and MGH led to the development of a new processing method for highly crosslinked UHMWPE that utilized mechanical deformation to reduce free radical concentration. This case study outlines the testing that demonstrated the efficacy of this technique. View Full PDF View […]

Did Your Biocompatibility Study Fail? Trace Level Analysis to the Rescue

Did Your Biocompatibility Study Fail? Trace Level Analysis to the Rescue

A failed cytotoxicity test can raise red flags for medical device development. To pinpoint the culprit, analyze the test media from the failed test. By tracing the analysis back to the bill of materials (BOM) and processing aids, the specific component responsible can often be identified. If the identified compound poses no toxicological risk in […]