Cambridge Polymer Group, a premier contract R&D lab supporting medical device, pharmaceutical, consumer products and industrial companies, is moving to a new 17,000 SF facility on August 5, 2021. After two decades in Boston’s Charlestown neighborhood, CPG is relocating to Cummings Properties’ TradeCenter 128 campus in Woburn to accommodate rapid growth.
Conveniently situated on Route 128/I-95 on the Burlington/Woburn line, the new facility was chosen to fulfill Cambridge Polymer Group’s requirement for a large, customizable, highly technical space. The 117% increase in custom-built lab space will allow us to meet the growing demand for our varied, specialized analytical testing and research & development services. The additional capacity accommodates the ongoing expansion of our product development, chromatography, and extractables & leachables departments.
Since the Woburn site is only 12 miles north of our Charlestown location, CPG will be retaining existing staff. The 11% increase in office space provides room for a welcoming reception area, a spacious conference room, and more cubicles and offices, allowing for the acquisition of additional team members. Our new location offers plenty of free parking for both employees and visitors.
As an ISO 9001:2015 certified and ISO 17025:2017 accredited (Cert # 3930.01) testing laboratory, CPG takes quality very seriously. We are implementing a carefully planned phase approach to the relocation, designed to ensure a smooth transition. Our plan minimizes workflow disruptions and meticulously maintains the integrity of project research and instrument calibration.
New Cambridge Polymer Group Address
Cambridge Polymer Group, Inc.
100 TradeCenter Drive, Suite 200
Woburn, MA 01801
Our contact numbers will remain the same, including our main number: 617-629-4400.
For Clients
As of July 30, 2021, we will no longer be able to accept samples at 56 Roland Street, Suite 310, Boston, MA 02129. A sample submission form with our new location details is posted on our website and linked in our email signature.
If you would like to see Cambridge Polymer Group’s new space and meet our team of PhD problem solvers, please email info@campoly.com to schedule a visit.
For Vendors
Shipments should be delivered to our dedicated loading dock. For questions about deliveries, contact Receiving at receiving@campoly.com or 617-629-4400, ext. 21.
Turmeric, the orange-yellow root of the Curcuma longa, has been used as a spice, medicine, and dye for at least 4,500 years. Turmeric consists of hundreds of compounds, but the curcuminoid curcumin is a major component of most commercial extracts. Although recent lab and animal research has found curcumin to contain anti-inflammatory and antioxidant capabilities, curcumin’s efficacy in human trials remains controversial, and trials have been limited due to its lack of oral bioavailability and rapid plasma clearance.
Drug vs. Supplement
Although the pharmaceutical industry has thus far viewed curcumin as a poor therapeutic agent, the nutraceutical industry does not have to prove efficacy to market curcumin for the treatment of disease. Because dietary supplements are not subject to the same FDA regulations as pharmaceuticals, there are currently no requirements that supplement labels be proven accurate or truthful. As a result, some marketed supplements contain less, or sometimes none, of the active ingredient they claim to contain.
Samples were obtained from a commercial supplement with a label indicating 180 mg of curcumin per capsule. Curcumin purchased from Sigma Aldrich was used as a control. The percentage of curcumin in the control was consistent with the percentage reported by Sigma Aldrich’s label.
However, CPG found 40% less curcumin in the commercial curcumin supplement than advertised on its label. This deformulation shows that it is important for manufacturers to screen incoming raw materials for purity using validated testing techniques.
Additionally, manufacturers can voluntarily submit products for certification by either the United States Pharmacopeia (USP) or National Science Foundation (NSF). A seal from either of these groups indicates that the consumer can trust that the product has been verified to contain the ingredients listed. As an ISO 17025 accredited and 9001 certified lab, CPG can test to USP standards and certify results.
Dextran, a polysaccharide made from glucose, is widely used in the medical field for treatment of shock, as an antithrombotic agent, to reduce blood viscosity, and as an anticoagulant. The two most common forms are dextran 40 and dextran 70 (the 40 and 70 refer to their molecular weights, nominally 40,000 and 70,000 g/mol).
The USP monographs for dextran 40 and 70 describe a specific gel permeation chromatography approach that differs in success criteria from other GPC methods, and requires a unique GPC system setup and data analysis method. To qualify a dextran formulation under these USP guidelines, the material must be tested by this GPC method.
A calibration curve is constructed with dextrose and five dextran standards of known molecular weights, using either a Gauss-Newton method or the Nilsson-Nilsson method to determine the constants in the expression below for each of the standards based on their reported molecular weights Mi.
Mi = b5 + exp(b4 + b1Ki + b2Ki2 + b3Ki3)
Each of the standards must meet a rigorous accuracy check to ensure the GPC system is adequately set up to test the specific dextran samples and to ensure they meet the requirements of the USP monographs. Once the equipment is properly validated by this method, the samples can be tested.
A CPG twist on a holiday classic, with happier results
Paraxanthine and Theophylline sat at their Thanksgiving table.
“What have I got to be thankful for?” grumbled Xan. “No one’s ever heard of me. Caffeine gets all the hype, even though I’m more potent with less of the negative side effects. I want to be recognized for being better at blocking adenosine receptors. I want to see my formula on t-shirts and mugs! I want to be the name people whisper desperately as they stumble towards their kitchens.”
“If you don’t like your life, change it,” suggested Theo.
“Self-help mantras are well and good for humans, but what’s an organic compound to do? The holidays are so depressing. Another year gone by, and what have I got to show for it?”
While Xan continued to whine about the winter of her discontent, Theo googled “Formulation and Chemical Synthesis” and requested a quote from Cambridge Polymer Group.
Theo announced, “Xan, I’m going out now to get you a present. I’ll be back in 10-15 days.”
This revelation distracted Xan from her navel gazing. “Theo is getting me a gift??? I wonder what it could be?”
Ten days later, FedEx left a package on Xan’s doorstep. She rushed out to grab the box, which was almost stolen by porch pirates.
“Maybe it’s Theo’s present,” Xan thought excitedly. She opened the package and nearly lost her electrons when Theo jumped out of the box.
“Theo, is that really you?” Xan eyed him suspiciously, “You look a little different…”
“Here Xan,” said the Caffeine formerly known as Theo, “Have a carbon dihydride. If you can’t beat ‘em, join ‘em.”
“Oh, thanks so much,” gushed Xan, as she accepted his gift. “But now I’m Caffeine and you’re not, and I have nothing to give you.”
“That’s OK, Xan-I mean, Caff. I gave you my position 1 carbon dihydride, so I’m Theobromine now. We can be chocolate together.”
ISO and ASTM are drafting a new standard on qualification of polymeric materials used for additive manufacturing using powder bed fusion (ISO/ASTM DIS 52925:2020). This standard is focused on polyamide 12 and 11, but the standard may be applicable to other polymeric materials.
The standard discusses the following test methods:
These tests are all performed by Cambridge Polymer Group, and can be used to qualify new material or requalify used material. Contact us for more information.
The ASTM workshop on Reprocessing Personal Protective Equipment (September 9-10, 2020, virtual workshop) is looking for presentations on the following topics:
Methods/guides/practices to address reprocessing single use PPE and reusable PPE (including N95 respirators, personal face masks, protective clothing and coverings, etc.):
Current issues with decontaminating single use PPE
Cleaning
Index matching
Collection and distribution
Loss of efficacy
Degradation of components
Tracking number of re-uses
Cleaning/decontamination/sterilization
New sterilization/disinfection methods – chlorine dioxide, etc.
Assessing performance of the reprocessed device, including feedback from healthcare providers who have used reprocessed devices
Effects of bioburden on re-use, for disinfection and perception
Standards used
Existing: ASTM, NIOSH and other
Include limitations, such as multiple decontaminations
Novel test methods introduced by researchers during the COVID-19 outbreak
Methods/guides/practices for producing and or assessing performance of devices and device components that are in short supply
e.g. masks, respirators, and face shields
Both traditional device designs and novel designs using materials that are at hand
Redesigning single use PPE for potential re-use during surges
Discussion of FDA Emergency Use Authorizations (EUAs),
For current EUAs, the impact on supply chain and on products/methods covered by current EUAs.
Considerations needed to continue product access upon EUA expiration including impacts on the supply chain and on products/methods covered by current EUAs.
Share perspectives on how existing standards helped you in addressing device shortages or how they could have been of more assistance
Abstract Submittal
To participate in the workshop, your 300-word abstract is due no later than July 26, 2020. Please see the ASTM symposium page for submission instructions.
The Australian thorny devil (meloch horridus) is a desert-going lizard that has developed an impressive application of transport phenomenon to make the most of a limited source of water in the arid regions it inhabits.[1] The lizard has a skin surface that contains a continuous series of micro-channels that are capable of transporting water by capillary action towards the lizard’s mouth. As the lizard crawls over and under vegetation that contains droplets of dew, it effectively collects this water all over its body, allowing it to drink on the run. The lizard’s mouth, suitable for eating ants, is not adapted to drink water directly, necessitating this curious mode of drinking.
Capillary Transport in Nature
Capillary transport is quite common in nature. It is the mechanism by which water is moved from the roots of trees up to its leaves. It is the means that our eyes drain tear fluid through the narrow tear ducts in our eyelids. This ability results from the attractive nature that water molecules have for each other, termed the forces of cohesion. This cohesion leads to surface tension, or the resistance of the surface of a liquid to an external force, such as a solid object penetrating the liquid. This tensile force causes the liquid to form a meniscus when placed in a narrow capillary, and if sufficient adhesion occurs between the water and the capillary wall, the water will be pulled along in the capillary, even overcoming the force of gravity if the capillary diameter is sufficiently small.
While this mode of drinking may appear convenient, one could argue that the quaffable benefits of the thorny devil’s capillary-driven drinking mechanical are outstripped by the social liability of its crenulated dermis. But from a surface science point of view, the thorny devil has arrived at a low energy, high efficiency method of harvesting water.
For more information on surface energy measurements, contact Cambridge Polymer Group or visit our website.
[1] Comanns et al. “Adsorption and movement of water by skin of the Australian thorny devil (Agamidae: Moloch horridus),” (2017) https://doi.org/10.1098/rsos.170591
CPG is now fully open and able to work on ALL projects; we are no longer limited to COVID-19 response or projects essential for medical emergency staff. Turnaround times may still be affected due to the need to social distance.
Cambridge Polymer Group is in compliance with Massachusetts Governor Baker’s May 18th re-opening schedule. CPG has been deemed an essential business, and has implemented all safety precautions stipulated by the re-opening order, as well as additional safety measures.
CPG COVID-19 Visitor Policy
Cambridge Polymer Group is committed to providing a safe environment for our employees and visitors. For the protection of all, we’ve implemented the following requirements:
Upon entering the facility, all persons must:
Have a face mask or covering
Undergo a temperature and symptom screening
Promptly wash hands
Comply with social distancing practices at all times
While in the laboratory, all persons must:
Wear proper personal protective equipment including gloves and safety glasses
Wash hands upon exiting
In addition to these requirements, Cambridge Polymer Group has increased the frequency of cleaning and disinfection of the workplace. These policies and procedures have been implemented to reduce transmission risks and protect our workforce. Your cooperation is appreciated.
Dropping Off Samples
If you are dropping off samples and do not need to enter our office or lab space, follow these steps:
Notify your CPG contact of the time you intend to drop off samples.
Enter the 56 Roland Street building at the North Lobby entrance. Take the stairs or the elevator to the third floor. Follow the signs to Cambridge Polymer Group.
Leave your samples and SSF form on the stool to the left of CPG’s door, under the USPS/UPS/Fedex sign. We will retrieve them after you leave.
CPG employees are making masks for friends, family, neighbors, hospital workers, and the Boston Mask Initiative. Because most stores are closed due to COVID-19, CPG mask makers put their material selection skills to good use while scavenging household supplies. We pooled our mask-making and mask-wearing experiences into the following suggestions:
#1 – Fit Is Most Important
Better fitting masks are both more effective at preventing coronavirus transmission and less likely to fog glasses, so look for a pattern/design with less opening in the top and sides. Gaps can decrease a mask’s effectiveness by over 60%. Your mask should start at the bridge of your nose and end underneath your chin. If your mask does not fit properly, do not keep wearing it.
#2 – Use Two Layers, at a Minimum
The CDC recommends that masks should be made of at least two layers. One of our scientists suggests pellon as an inner layer, but acknowledges that it is hard to find in stock. She says any material made of non-woven polypropylene will work as an inner filter (such as bags from running shoe stores).
Filtration efficiency of a cloth mask comprised of high thread count cotton (left/green) and one layer of flannel or two layers of silk or two layers of chiffon (right/blue). Credit: ACS Nano
A recent University of Chicago study found that a hybrid of mask materials provided significant protection from aerosol particles. For the outside of the mask, the study recommends using one layer of tightly woven cotton as a mechanical filter. For the inside of the mask, either flannel (one layer), or silk (two layers), or chiffon (two layers) functions as an electrostatic filter, though not quite as effectively as an N95. For an explanation of how electrostatic filters work, see our N95 app note.
Where to find tightly woven cotton around your house? Look for 400-600 count cotton pillow cases or sheets, quilting cotton, or cotton dish towels.
Unless you know a fashionista willing to let you cut up expensive clothing, it’s unlikely you have access to spare silk and chiffon for the inner section of your mask. Flannel is more commonly available; bed sheets or pajamas are two sources you may already have. The downside of flannel is that it tends to be warm – it might be worth ordering some chiffon for summer masks.
#3 – Secure with Elastic or Fabric Ties
Elastic has been sold out from very early in the pandemic. Our mask-making scientists got creative, using hair band elastics, elastic beading cord, bungee cords (the type used for swim goggles), and pieces of straps from old swim suits.
Other mask makers used fabric ties instead of elastic loops. Some of our staff found that masks with ties are more comfortable on the ears and easier to adjust than masks with elastic loops.
Those who prefer elastic but dislike sore ears sewed buttons onto surgical caps or headbands, or used 3D printed straps. The elastic is wrapped around the button or the 3D printed guard instead of the ear.
#4 – Metal Nose Clip
A metal nose clip shapes the mask to your facial contours and reduces lens fogging. Possible sources of metal include: hair barrettes, disposable foil baking pans, pipe cleaners, paper clips, and plastic coated metal twist ties (such as the kinds used for bread or for vine training). If your mask contains metal, DO NOT MICROWAVE to disinfect. Instead, hand or machine-wash your mask or leave it in direct sunlight.
#5 – Padding
Some CPG staff decided to pad the nose section of the mask with foam, both for improved seal and comfort over the course of a lab shift. Where to find foam around your house? One possible source is shipping wrap from all of those packages you’ve been ordering. If you have any broken headphones lying around (don’t worry, we won’t tell Marie Kondo), they may contain memory foam. Insoles from old sneakers are another potential source of memory foam, but may be too smelly to use.
#6 – Extra Stocking Layer
To further enhance your mask’s seal and boost its effectiveness, a recent Northeastern University study recommends wearing a nylon stocking layer over a cloth mask. The study suggests cutting 8-10 inches off the leg of a Q size stocking.
Disclaimer: the Northeastern study was released prior to peer review. However, it was inspired by previous research which found a layer of hosiery over a homemade mask was effective at filtering fallout particles from the 1979 Three Mile Island nuclear disaster.
Some CPG staff decided the stocking layer was too tight and difficult to breathe through (though perhaps we just have larger-than-average heads). In one case, the intense seal around the mouth led to the wetting of both layers of mask cotton with breath moisture. It is essential that your mask remain dry, since natural fibers can swell when wet, impacting mask performance. In our extremely casual observation, wearing the nylon layer did not seem to prevent glasses fogging, despite the improved seal.
#7 – Surgical Tape
Use surgical or sports tape to seal the top of your mask to your face to reduce fogging. DO NOT USE packing or duct tape which can cause skin abrasions. Surgical and sports tape adhesive is designed to allow transmission of air and moisture through the adhesive system, which minimizes skin irritation.
#8 – Glasses Positioning
Positioning your glasses/lab goggles on top of the mask can also decrease fogging. Adding either 1) a metal nose clip or 2) padding to the bridge of the nose or 3) bias tape to the top of the mask can help to create a perch for your glasses or goggles to rest on. Most CPG employees found wearing glasses or goggles on top of the mask (with or without a perch) to be the most effective method of reducing or eliminating lens fog.
After taking your mask off, clean your glasses before putting them back on your face since they were just touching the contaminated part of your mask.
Cambridge Polymer Group owns two 3D printers, a PRUSA and a Leapfrog Xeed. We use them for making prototypes and creating custom instrument parts. When Massachusetts Governor Baker issued the shelter-in-place order on March 23rd, we brought our printers home, so that we could join the worldwide movement to alleviate the shortage of personal protective equipment caused by the coronavirus pandemic. The PRUSA called shotgun, so the Leapfrog Xeed had to ride in the backseat.
In the weeks that followed, CPG employees continued to work remotely, and some of us returned to the lab to work on COVID-19 related projects. During down time, our CPG 3D printer operators set to work producing PPE, including CPAP brackets, face shields and ear guards.
CPAP Brackets For Italian Infants
Cambridge Polymer printed brackets for CPAP units shipped to Italy in anticipation of infants suffering from COVID-19.
Face Shields For Medical Professionals
CPG also printed face shields for Massachusetts healthcare workers.
Plastic Straps For Ear Relief
While working in the lab on COVID-19 related projects, CPG scientists discovered firsthand that elastic mask loops cause ear friction. Our CPG 3D printer operators came to the rescue with ear savers. Invented by a 12-year-old Canadian Scout, the 3D printed guard pulls the elastic away from the ears, preventing the elastic from rubbing the ears raw and improving mask fit.
Face Shield Fails For Comic Relief
“Virtually nothing comes out right the first time. Failures, repeated failures, are finger posts on the road to achievement. One fails forward toward success.” – Charles F. Kettering
